FDA, CDC poised to make call on mixed COVID-19 boosters

 

The Food and Drug Administration (FDA) as early as today may approve “mix and match” booster shots, meaning people can get a different COVID-19 vaccine from the one administered during their initial series if they need a booster.

Sources told the Washington Post the FDA could make the announcement at the same time it authorizes booster doses for some Moderna recipients, and all Johnson & Johnson (J&J) recipients.

The move is based on early data presented to the FDA late last week from the National Institutes of Health, as well as evidence from the European Union and United Kingdom, where mixed dosing has been used successfully.

The announcement will likely offer guidance to the 15 million Americans inoculated with the Johnson & Johnson (J&J) vaccine, which has proved less effective than either the Pfizer or Moderna vaccines. Though J&J recipients could choose to get a second dose of that vaccine, they could also choose to mix their initial adenovirus-based vaccine with an mRNA shot. This strategy, called heterologous prime-boosts, has been shown to be well-tolerated.

 

 

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